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Clozapine-Related Seizures Neurol 41:369-371, Devinsky,O.,et al, 1991 See this aricle in Pubmed Article Abstract Clozapine is an atypical antipsychotic drug with minimal extrapyramidal toxicity recently approved by the Food and Drug Administration for hard- to-treat schizophrenic patients.We reviewed information on 1,418 patients treated with clozapine in the United States between 1972 and 1988.Forty- one of 1,418(2.8%)patients had generalized tonic-clonic seizures during treatment with clozapine.Life-table analysis predicts a cumulative 10%risk of seizures after 3.8 years of treatment.Clozapine-related seizures appear to be dose-related.High-dose therapy(>/=600 mg/day)was associated with a greater risk of seizures(4.4%)than medium(300 to 600 mg/day;2.7%)or low doses(<300mg/day;1.0%).Also,rapid upward titration may increase seizure risk.Thirty-one of 41 patients were successfully continued on clozapine despite seizure occurrence,either with reduction of dose or addition of an antiepileptic medication.Recognition and treatment of clozapine-related seizures will become increasingly important as its use grows in the 1990s.

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(click to filter results - removes previous filter) adverse drug reaction clozapine seizure seizure,drug-induced

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